Longitudinal mRNA expression analysis of the adaptive response to Enzalutimde in LNCaP cells

ABSTRACT: The aim of this study is to investigate metabolic alterations involved in the adaptive response of prostate cancer cells to androgen-deprivation therapy (ADT) and AR-targeted therapies (ATTs) in hopes of identifying novel targets to help delay progression to castrate-resistant prostate cancer (CRPC). We developed an in vitro model of long-term ATT and used transcriptomics, proteomics and lipidomics to identify metabolic pathways contributing to cell survival.

ORGANISM(S): Homo sapiens

PROVIDER: GSE143408 | GEO | 2020/06/29

REPOSITORIES: GEO