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Monitoring the differential expression of miRNAs, tRNAs and tRFs in lung cancer biopsies.

ABSTRACT: Translational rate has been deregulated in many cancers through small non-coding RNAs aberrations. Herein we focus on miRNAs, tRNAs and tRFs paterns in lung cancer biopsies.

ORGANISM(S): Homo sapiens

PROVIDER: GSE143694 | GEO | 2023/01/01

REPOSITORIES: GEO

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tRFs and tiRNA expression profile in human OA ACL cells and NA ACL cells.

Project description:tRNA-derived fragments (tRFs) are new noncoding RNAs, and recent studies have shown that tRNAs and tRFs have important functions in cell metabolism via posttranscriptional regulation of gene expression. However, whether tRFs regulate cellular metabolism of the anterior cruciate ligament (ACL) remains elusive. The aim of this study was to investigate the role and action mechanism of tRFs in ACL cell metabolism. Arraystar_tRF&tiRNA was used to determine tRFs and tiRNA expression profiles in human OA ACL cells and NA ACL cells。

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tRNA-seq and YAMAT-seq profiling the expressions of tRNA-derived fragments and tRNAs in plants

Project description:Here, we apply tRNA-seq and YAMAT-seq to profile the expressions of tRFs and tRNAs in plants. We provide a high-quality expression atlas of tRFs and tRNAs in Arabidopsis and rice, and uncover complex tRF population and the dynamic expressions of tRNA genes in plants.

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Contribution of miRNAs, tRNAs and tRFs to Aberrant Signaling and Translation Deregulation in Lung Cancer.

Project description: Not available

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tRNA fragments (tRFs) analysis of small RNA libraries

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tRFs quantification in HaCaT cell culture

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Quantification of tRNA-derived fragments in Arabidopsis and rice

Project description:Here, we adopt a method that combines tRNA-seq and cp-RNA-seq to identify and quantify tRFs and tRNAs in plants. We provide a high-quality expression atlas of tRFs and tRNAs in Arabidopsis and rice, and uncovers complex tRFs repertoire and the dynamic expressions of tRNA genes in plants.

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Identification of tRFs&tiRNAs Expression Profile in Breast Cancer Tissues

Project description:Purpose:In recent years, tRFs(transfer RNA-Derived Fragments) & tiRNAs (transfer RNA-Derived Stress-induced RNAs or tRNA halves) have been shown to have vital roles in cancer biology. We aimed to reveal the expression profile of tRFs&tiRNAs in breast cancer tissues in the study, and to explore their potential as biomarkers of breast cancer. Methods:We characterize tRFs&tiRNAs expression profiles in 6 pairs of breast cancer tissues and adjacent normal samples.Then we selected six tRFs&tiRNAs with significant expression and added 10 pairs of samples to verify the selected genes by qPCR in 16 pairs of breast cancer tissues along with the previous 6 pairs. Results:We found 31 differentially expressed tRFs&tiRNAs across our dataset, out of which 17 were up-regulated, 14 were down-regulated. Compared with 16 breast cancer tissues and healthy controls by qPCR, the results demonstrated that AS-tDR-001430, AS-tDR-001130 and AS-tDR-000779 were significantly expressed in breast cancer tissues (p < 0.001). AS-tDR-000779 was significantly up-regulated, AS-tDR-001430 and AS-tDR-001130 were significantly down-regulated which the expression patterns were similar to the sequencing results. Conclusions:Our studies have demonstrated that there were significantly expressed tRFs&tiRNAs in breast cancer tissues. They are hopefully to become biomarkers and would be valuable researches in this area.

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2023-01-31 | GSE212737 | GEO

tRNAs marked with CCACCA are targeted for degradation

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2011-11-17 | E-GEOD-33756 | biostudies-arrayexpress

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