Transcriptomics,Genomics

Dataset Information

18

Characterization of expression changes in armi,rhino,aub,ago3 mutants by tiling array


ABSTRACT: We characterized changes of transposon and mRNA expressions in armi, rhino ,aub, ago3 mutants with respect to wild type using Affy tiling array. In most of these mutants, mRNA expressions were mostly unchanged but increased expressions was observed for many transposons indicating the role of these proteins in silencing transposons in Drosophila ovaries Keywords: Tiling array transcriptome profiling Overall design: 3 replicates of each mutants and wild type, total RNA samples hybridized to tiling array.

INSTRUMENT(S): [DM_tiling2_MR] Affymetrix Drosophila Tiling 2.0R Array

SUBMITTER: Hualin Xi   

PROVIDER: GSE14370 | GEO | 2009-05-03

SECONDARY ACCESSION(S): PRJNA111411

REPOSITORIES: GEO

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Publications


Piwi-interacting RNAs (piRNAs) silence transposons in animal germ cells. piRNAs are thought to derive from long transcripts spanning transposon-rich genomic loci and to direct an autoamplification loop in which an antisense piRNA, bound to Aubergine or Piwi protein, triggers production of a sense piRNA bound to the PIWI protein Argonaute3 (Ago3). In turn, the new piRNA is envisioned to produce a second antisense piRNA. Here, we describe strong loss-of-function mutations in ago3, allowing a direc  ...[more]

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