Gene expression of CD4+ T cells in response to antigen persisting at different doses for different times

ABSTRACT: Chronic infections and cancer can induce a dsyfunctional immune response which cannot clear the cause of disease. We asked how antigen persistence alone affects T helper cell reactivity v. exhaustion and compared the gene expression of CD4+ T cell responding to antigen persisting at different levels for different periods of time. We used microarrays to detail gene expression underlying T helper cell dysfunctionality evolving in response to different levels of antigen at two timepoints.

ORGANISM(S): Mus musculus

PROVIDER: GSE143733 | GEO | 2020/12/18

REPOSITORIES: GEO