Genomics

Dataset Information

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Knocking out C9ORF72 exacerbates axonal trafficking defects associated with hexanucleotide repeat expansion and reduces levels of heat shock proteins I


ABSTRACT: iPSCs with mutant C9ORF72 were edited using CRISPR/Cas9 (1) to knockout C9ORF72 or, alternatively, (2) to correct the ALS mutation, followed by differentiation into motor neurons.

ORGANISM(S): Homo sapiens

PROVIDER: GSE143743 | GEO | 2020/01/17

REPOSITORIES: GEO

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