Transcriptional profiling of distinct fibroblast populations in the pancreatic tumor microenvironment

ABSTRACT: Pancreatic stellate cells are thought to be the predominant source of cancer-associated fibroblasts (CAFs) in pancreatic cancer. We developed a mouse model which allows us to track and analyze stellate cells and stellate cell-derived CAFs in vivo during pancreatic tumorigenesis for the first time. We find that stellate cells in fact give rise to a minority of all CAFs. Here, we have used lineage reporters to isolate stellate cell-derived and non-stellate cell-derived CAFs and compared them by RNA-seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE143805 | GEO | 2021/09/16

REPOSITORIES: GEO