Describing molecular coupling of the estrogen receptor and coregulators and its crosstalk with retinoic acid receptors in breast cancer

ABSTRACT: Purpose: We exploit transcriptomic data to shed light on the functional consequences of ER-RAR crosstalk mediated by RIP140 and LCoR. We compare ligand-stimulated conditions with and without knocked down of RIP140 and LCoR. We also assess the additive versus synergistic nature of global transcriptional changes by comparing separate 17-β estradiol (E2) and retinoic acid (RA) induced transcriptomes with the transcriptome induced by simultaneous E2 and RA stimulation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE143956 | GEO | 2021/03/31

REPOSITORIES: GEO