Transcriptomics,Genomics

Dataset Information

19

Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth


ABSTRACT: Transcpripts upregulated by both BCG and PPD were identified in 5 infants and pathway analysis and gene ontology were performed using differentially expressed genes Keywords: response to antigen stimulation Overall design: In this study the frozen PBMC of 5 infants were thawed and stimulated for 12 hours with either BCG or PPD or rested in media alone for 12 hours. The transcripts from the unstimulated PBMC were compared to the PPD and BCG induced transcripts

INSTRUMENT(S): Sentrix HumanRef-8 Expression BeadChip

SUBMITTER: Helen Alison Fletcher   

PROVIDER: GSE14408 | GEO | 2009-02-24

SECONDARY ACCESSION(S): PRJNA111801

REPOSITORIES: GEO

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Publications

Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth.

Fletcher Helen A HA   Keyser Alana A   Bowmaker Mark M   Sayles Peter C PC   Kaplan Gilla G   Hussey Greg G   Hill Adrian V S AV   Hanekom Willem A WA  

BMC medical genomics 20090224


Novel tuberculosis (TB) vaccines recently tested in humans have been designed to boost immunity induced by the current vaccine, Mycobacterium bovis Bacille Calmette-Guérin (BCG). Because BCG vaccination is used extensively in infants, this population group is likely to be the first in which efficacy trials of new vaccines will be conducted. However, our understanding of the complexity of immunity to BCG in infants is inadequate, making interpretation of vaccine-induced immune responses difficult  ...[more]

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