Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A549-derived exosomes transform fibroblasts into cancer-associated fibroblasts

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE144178 | GEO | 2025/12/31

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

A549-derived exosomes transform fibroblasts into cancer-associated fibroblasts (microRNA)

Project description:The communication between tumor-derived exosomes and stroma plays a critical role in facilitating cancer progression. We detected the mRNA expression levels after MRC5 was transfected with shRNAs targeting FOXN3 or incubated with A549 cells-derived exosomes. We reported that in lung cancer microenvironment, tumor cells exhibit a great capacity to convert normal fibroblasts (NFs) to cancer-associated fibroblasts (CAFs). We showed that tumor cells secrete a subset of exosomal microRNAs directly targeting FOXN3, which leads to the activation of fibroblasts. Activated CAFs further promote cancer growth by entering tumor tissues. These results demonstrate that intercellular crosstalk between tumor cells and fibroblasts is mediated by tumor-derived exosomes, providing potential targets for treatment of lung cancer.

2025-12-31 | GSE144177 | GEO

A549-derived exosomes transform fibroblasts into cancer-associated fibroblasts (mRNA)

2025-12-31 | GSE144176 | GEO

A549-derived exosomes transform fibroblasts into cancer-associated fibroblasts (CUT&RUN)

Project description:With the in-depth study of exosomes, it has been discovered that tumor-derived exosomes could transform normal fibroblasts into cancer associated fibroblasts (CAFs) and further affect metastasis and drug resistance of CAFs. FOXN3 was the target of tumor-derived exosomes. The understanding of downstream genes regulated by FOXN3 is nessesary. An alternative ChIP-seq method, CUT&RUN was applied to explored the downstream genes directly regulated by FOXN3

2025-12-31 | GSE225116 | GEO

A549-derived exosomes transform fibroblasts into cancer-associated fibroblasts

Project description:A549-derived exosomes transform fibroblasts into cancer-associated fibroblasts

| PRJNA602932 | ENA

A549-derived exosomes transform fibroblasts into cancer-associated fibroblasts (microRNA)

Project description:A549-derived exosomes transform fibroblasts into cancer-associated fibroblasts (microRNA)

| PRJNA602935 | ENA

A549-derived exosomes transform fibroblasts into cancer-associated fibroblasts (mRNA)

Project description:A549-derived exosomes transform fibroblasts into cancer-associated fibroblasts (mRNA)

| PRJNA602936 | ENA