Genomics

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Transcriptional profiles in pregnant women in response to vaccination


ABSTRACT: Vaccination in pregnancy is an effective tool to protect both the mother and infant. Vaccines against tetanus, pertussis and influenza are recommended for use in pregnancy and new vaccines with specific indications for pregnancy are in the clinical trials pipeline. However our understanding of the immune response to vaccination in pregnancy is incomplete. We compared the effect of pregnancy on early (24 hours) transcriptional responses to vaccination. Pregnant mice and women were immunised with Boostrix-IPV, a vaccine containing pertussis antigens. Overall design: Pregnant women and mice were immunised with Boostrix-IPV, a multivalent vaccine, which containing three pertussis antigens. Blood was collected from women before and after vaccination and RNA extracted for analysis by microarray.

INSTRUMENT(S): Agilent-041580 8x60K whole genome linc V1_V2 041579 (Probe name version]

ORGANISM(S): Homo sapiens  

SUBMITTER: January 3rd Weiner  

PROVIDER: GSE144540 | GEO | 2020-01-31

REPOSITORIES: GEO

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