Transcriptomics

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19

Transcriptome modulation analysis of cytomegalovirus-infected immature monocyte-derived dendritic cells


ABSTRACT: Analysis of dendritic cells (DCs) at 6h and 48h after infection with cytomegalovirus (CMV) versus non infected. CMV tends to induce immunosuppression followed by lasting immunity. DCs appear to play a role in this effect. Results provide insights into CMV/DC interactions and suggest mechanisms for CMV-regulated early immune response. Keywords: gene expression array-based, count Overall design: In the present study, immature monocyte-derived dendritic cells were generated from CMV neg healthy blood donors and infected or not with an endotheliotropic CMV strain. Gene expression modulation by the CMV infection was studied in a time course assay (non-infected - NI - vs 6h or 48h post-infection. Patient C has no 48h sample

INSTRUMENT(S): Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)

ORGANISM(S): Homo sapiens  

SUBMITTER: Franck Halary   

PROVIDER: GSE14490 | GEO | 2009-01-22

SECONDARY ACCESSION(S): PRJNA111545

REPOSITORIES: GEO

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