Genome-wide investigation of the dynamic changes of epigenome modifications after DNA methylation editing [ChIP-Seq]

ABSTRACT: The aim of this study was to investigate the stability of DNA methylation, the dynamics of different histone modifications and the changes in expression after genome-wide introduction of DNA methylation in promotor CpG islands. Therefore, the catalytic domain of DNMT3A was fused to a zinc finger protein and expressed for three days to globally introduce de novo DNA methylation and subsequently, the changes in the epigenome were monitored for up to eleven days.

ORGANISM(S): Homo sapiens

PROVIDER: GSE144928 | GEO | 2020/11/10

REPOSITORIES: GEO