Cortical kidney bulk RNA Sequencing in the reversible unilateral ureter obstruction model.

ABSTRACT: The kidney has limited capacity to regenerate following injury and preferentially repairs chronic injury with secreted extracellular matrix proteins. This can be a progressive process with functioning kidney tissue being replaced detrimentally with fibrotic scar tissue, ultimately leading to kidney failure. Using the reversible unilateral ureteric obstruction model, a model of reversable injury, we describe the transcriptomic changes that occur during obstructive renal injury and subsequent repair.

ORGANISM(S): Mus musculus

PROVIDER: GSE145053 | GEO | 2020/09/27

REPOSITORIES: GEO