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RNA-seq of murine megakaryocyte progenitor cells treated with LSD1 inhibitor INCB059872

ABSTRACT: INCB059872 is a selective irreversible inhibitor of Lysine-Specific Demethylase 1 (LSD1) that is in phase 1 clinical trials in hematopoietic malignancies. We identified a population of cells within murine lineage-negative bone marrow that is expanded after treatment with INCB059872. Here we sorted cells from this population (Lin- Cd41+ Cd200r3-) and performed RNA-seq to measure gene expression changes caused by INCB059872. Consistent with the thrombocytopenia observed in LSD1i-treated mice, INCB059872 reduced expression of genes associated with platelet function.

ORGANISM(S): Mus musculus

PROVIDER: GSE145211 | GEO | 2020/05/28

REPOSITORIES: GEO

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Single-cell RNA-seq: INCB059872 in wild-type murine bone marrow

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RNA-seq of murine megakaryocyte progenitor cells treated with LSD1 inhibitor INCB059872

Project description:RNA-seq of murine megakaryocyte progenitor cells treated with LSD1 inhibitor INCB059872

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