The effect of CDK6 expression on DNA methylation and DNMT3B regulation

ABSTRACT: We performed methylation analyses in BCR-ABL+ cells either expressing or lacking CDK6 using the next-generation sequencing approach RRBS and identified DNA methylation changes towards both hyper- and hypomethylation. CDK6 mediated methylation changes are largely reverted by CDK6 re-expression in this experimental system.

ORGANISM(S): Mus musculus

PROVIDER: GSE145218 | GEO | 2020/11/24

REPOSITORIES: GEO