Dataset Information


A gene expression signature classifying telomerase and ALT immortalization

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)

SUBMITTER: W. Nicol Keith  

PROVIDER: GSE14533 | GEO | 2009-11-02



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A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT.

Lafferty-Whyte K K   Cairney C J CJ   Will M B MB   Serakinci N N   Daidone M-G MG   Zaffaroni N N   Bilsland A A   Keith W N WN  

Oncogene 20090817 43

Telomere length is maintained by two known mechanisms, the activation of telomerase or alternative lengthening of telomeres (ALT). The molecular mechanisms regulating the ALT phenotype are poorly understood and it is unknown how the decision of which pathway to activate is made at the cellular level. We have shown earlier that active repression of telomerase gene expression by chromatin remodelling of the promoters is one mechanism of regulation; however, other genes and signalling networks are  ...[more]

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