MiR-21 is critical in stress response and facilitates breast cancer development and metastasis [miRNA array]

ABSTRACT: miR-21 is upregulated in advanced tumor stages, distal metastasis, and poor survival and in response to cytotoxic stress, but is also known to confer resistance to radiation and chemotherapy. We discovered that global ablation of miR-21 significantly decreased tumorigenesis and metastatic spread of breast cancer, while sensitizing breast carcinomas to cytotoxic agents by evoking Fas/FasL-dependent apoptosis. Targeting miR-21 may represent a novel and efficacious therapeutic modality either alone or in combination with standard oncologic treatments.

ORGANISM(S): Mus musculus

PROVIDER: GSE145344 | GEO | 2022/02/01

REPOSITORIES: GEO