Gene expression profiling of tumor stroma of MCF7 breast cancer xenografts overexpressing podoplanin (mouse array)
Ontology highlight
ABSTRACT: Expression of the membrane glycoprotein podoplanin is upregulated in several human cancers and might be associated with their malignant progression. The exact biological function and molecular targets of cancer cell-expressed podoplanin have remained unclear, however. Here, we ectopically overexpressed podoplanin in a human breast carcinoma xenograft model to study its role in cancer progression. To identify potential molecular mediators of podoplanin-induced effects in the murine tumor stroma we compared transcriptional profiles of podoplanin-overexpressing and control tumors using mouse microarrays. Keywords: comparative transcriptional profiling
ORGANISM(S): Mus musculus Homo sapiens
PROVIDER: GSE14551 | GEO | 2010/05/25
SECONDARY ACCESSION(S): PRJNA114391
REPOSITORIES: GEO
ACCESS DATA
