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Gene expression profiling of MCF7 breast cancer xenografts overexpressing podoplanin

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

OTHER RELATED OMICS DATASETS IN: PRJNA114391PRJNA114509PRJNA111731

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE14552 | GEO | 2010/05/25

SECONDARY ACCESSION(S): PRJNA111731

REPOSITORIES: GEO

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Gene expression profiling of MCF7 breast cancer xenografts overexpressing podoplanin (human array)

Project description:Expression of the membrane glycoprotein podoplanin is upregulated in several human cancers and might be associated with their malignant progression. The exact biological function and molecular targets of cancer cell-expressed podoplanin have remained unclear, however. Here, we ectopically overexpressed podoplanin in a human breast carcinoma xenograft model to study its role in cancer progression. To identify molecular mediators of podoplanin-induced effects we compared transcriptional profiles of podoplanin-overexpressing and control tumors. Keywords: comparative transcriptional profiling

2010-05-25 | GSE14550 | GEO

Gene expression profiling of tumor stroma of MCF7 breast cancer xenografts overexpressing podoplanin (mouse array)

Project description:Expression of the membrane glycoprotein podoplanin is upregulated in several human cancers and might be associated with their malignant progression. The exact biological function and molecular targets of cancer cell-expressed podoplanin have remained unclear, however. Here, we ectopically overexpressed podoplanin in a human breast carcinoma xenograft model to study its role in cancer progression. To identify potential molecular mediators of podoplanin-induced effects in the murine tumor stroma we compared transcriptional profiles of podoplanin-overexpressing and control tumors using mouse microarrays. Keywords: comparative transcriptional profiling

2010-05-25 | GSE14551 | GEO