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GATA2 and progesterone receptor interaction in endometrial stromal cells undergoing decidualization

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE145674 | GEO | 2020/02/22

REPOSITORIES: GEO

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GATA2 and Progesterone Receptor Interaction in Endometrial Stromal Cells Undergoing Decidualization.

Project description: Not available

| S-EPMC7899565 | biostudies-literature

GATA2 and progesterone receptor interaction in endometrial stromal cells undergoing decidualization [ChIP-Seq]

Project description:The zinc-finger transcription factor GATA2 has been shown to be important for endometrial stromal cell decidualization in early pregnancy in mice and humans. Progesterone and its receptor PGR is also critical during decidualization but its interaction with GATA2 in regulating genes and pathways necessary for decidualization in human endometrium are unclear. Human endometrial stromal cells were isolated from 5 premenopausal women for primary cell culture. The cells underwent in vitro decidualization (IVD) or vehicle (Veh) treatment for 10 days. RNA-sequencing (RNA-seq) was performed to compare gene expression profiles (n=3) and chromatin immunoprecipitation followed by sequencing (ChIP-seq) using an antibody against GATA2 (n=2) was performed to examine binding to target genes in the Veh and IVD cells. A public PGR ChIP-seq dataset (GSE69539) was mined to identify PGR-binding regions in IVD-treated human endometrial cells.

2020-02-22 | GSE145673 | GEO

GATA2 and progesterone receptor interaction in endometrial stromal cells undergoing decidualization [RNA-Seq]

2020-02-22 | GSE145671 | GEO

GATA2 and progesterone receptor interaction in endometrial stromal cells undergoing decidualization

Project description:GATA2 and progesterone receptor interaction in endometrial stromal cells undergoing decidualization

| PRJNA607922 | ENA

GATA2 and progesterone receptor interaction in endometrial stromal cells undergoing decidualization [ChIP-Seq]

Project description:GATA2 and progesterone receptor interaction in endometrial stromal cells undergoing decidualization [ChIP-Seq]

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GATA2 and progesterone receptor interaction in endometrial stromal cells undergoing decidualization [RNA-Seq]

Project description:GATA2 and progesterone receptor interaction in endometrial stromal cells undergoing decidualization [RNA-Seq]

| PRJNA607936 | ENA