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RNA secondary structome of different cell lines

ABSTRACT: we resolved the RNA secondary structure of human (HEK293, HeLa, K562, HepG2, H9) and mouse (mES) cells based on optimized in vivo click selective 2'-hydroxyl acylation and profiling experiment (icSHAPE). we describe a deep discriminative neural network (PrismNet) that integrates big data of RBP binding and RNA secondary structure from matched living cells and accurately models the RNA sequence and structural preferences of protein-RNA interactions in vivo, enabling precise prediction of the perturbation effects of genetic variants.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE145805 | GEO | 2021/02/05

REPOSITORIES: GEO

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