Nrf2 and HIF1α merge to arsenic-induced metabolic reprogramming and formation of the cancer stem-like cells.

ABSTRACT: Arsenic (iAs) induces generation of the cancer stem-like cells (CSCs) through Nrf2-dependent HIF1α activation, and the subsequent metabolic reprogramming from mitochondrial oxdaive phosphorylation to glycolysis in epithelial cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE145834 | GEO | 2020/02/25

REPOSITORIES: GEO