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The CTD of EBF1 enhances Brg1 recruitment to chromatin

ABSTRACT: EBF1 binds lymphoid progenitor chromatin prior to the detection of chromatin accessibility, whereby a C-terminal domain (CTD) enables “pioneering” independently of cooperating transcription factors. The CTD of EBF1 includes a short prion-like domain (PLD) with an ability of liquid-liquid phase separation in vitro and in vivo. The PLD of EBF1 mediates the recruitment of the chromatin remodeler Brg1 (a subunit of SWI/SNF remodeling complex).

ORGANISM(S): Mus musculus

PROVIDER: GSE145991 | GEO | 2020/11/08

REPOSITORIES: GEO

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