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Investigation of methylation level change of Endothelial cells and Magnesium-based alloy treated Endothelial cells

ABSTRACT: We have completed the Arraystar Human m6A-mRNA&lncRNA Epitranscriptomic microarray analysis of the samples to validate the modulating role of Magnesium-based alloy on methylation of inflammatory genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE146038 | GEO | 2022/02/27

REPOSITORIES: GEO

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investigation of methylation level change of Endothelial cells and Magnesium-based alloy treated Endothelial cells

Project description:investigation of methylation level change of Endothelial cells and Magnesium-based alloy treated Endothelial cells

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Next Generation Sequencing Facilitates Quantitative Analysis of Endothelial cells and Magnesium-based alloy treated Endothelial cells Transcriptomes

Project description:mRNA-seq was conducted to validate the changed mRNA expression of Endothelial cells after contacting with Magnesium-based alloy discs compared with normal Endothelial cells.

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ChIP sequencing for Endothelial cells and Magnesium-based alloy treated Endothelial cells

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Transcription profiling of Bordetella pertussis GMT-1 magnesium sulfate shift

Project description:B. pertussis GMT-1 was grown in media containing magnesium sulfate to put the culture in the Bvg- phase. The cells were then washed and grown in media lacking magnesium sulfate and samples were harvested at time=0 and several time points beyond.

2006-03-31 | E-TABM-30 | biostudies-arrayexpress

Gene expression profiling in soybean under aluminum stress: mechanisms of magnesium amelioration of aluminum toxicity

Project description:Gene expression profiling in soybean under aluminum stress: mechanisms of magnesium amelioration of aluminum toxicity at gene expression level. Micro-molar concentrations of magnesium in culture solution has been shown to ameliorate Al toxicity in soybean and other leguminous species. Different theories have been proposed to explain the chemical mechanisms of how the two ions interact to neutralize the toxic effect of aluminum in the plant root system. To understand the molecular mechanisms of the phenomenon at the gene expression level in soybean, we undertook a comparative transcriptome analysis in Al-tolerant and Al-sensitive genotypes treated with aluminum alone or aluminum plus magnesium using DNA microarrays. The results revealed magnesium enhances Al-tolerance level in the Al-tolerant genotype by down-regulating genes commonly induced in response to Al toxicity. We hypothesized that the magnesium-mediated alleviation of Al toxicity in the Al-tolerant genotype emanates from reduction in energy expenditure of gene expression induced in response to Al stress. Conversely, magnesium appears to ameliorate Al toxicity in the sensitive genotype by dual mechanisms of increasing the expression level of several genes involved in Al-tolerance and decreasing the expression level of most genes. Keywords: Soybean, aluminum toxicity, magnesium, transcriptome Two genotypes: PI 416937 (p) and Young (y); two treatments: Aluminum (Al) or Al+magnesium (Mg); two time points: 12 and 72 hrs; 3 replicates.

2010-10-04 | E-GEOD-18518 | biostudies-arrayexpress

Root transcriptome remodeling of Arabidopsis in response to high levels of magnesium sulfate

Project description:Martian regolith (unconsolidated surface material) is a potential medium for plant growth in bioregenerative life support systems during manned missions on Mars. However, hydrated magnesium sulfate mineral levels in the regolith of Mars can reach as high as 10 wt%, and would be expected to be highly inhibitory to plant growth. A global approach was used to identify novel genes with potential to enhance tolerance to high MgSO4 stress. The early Arabidopsis root transcriptome response to elevated concentrations of magnesium sulfate was characterized in col-0, and also between col-0 and the mutant line cax1-1 – a mutant relatively tolerant of high levels of MgSO4•7H2O in soil solution. After 3 weeks of growth under hydroponic conditions, Arabidopsis thaliana col-0 roots were exposed to a basic nutrient solution (0.25 g/L MES, 1/16x MS, pH 5.7) with an additional 2.08 mM magnesium sulfate (total Ca:Mg ratio = 1:15) for 45 min., 90 min., or 180 min., while a col-0 control set was exposed to the basic nutrient solution without additional magnesium sulfate for 45 minutes. Arabidopsis thaliana cax1-1 roots were exposed to the basic nutrient solution with additional magnesium sulfate for 180 min. only. Four replicate containers were harvested for the control and each of the treatment sets, resulting in a total of 20 samples. Gene expression of the col-0 sets exposed to magnesium sulfate treatment for 45 min., 90 min., or 180 min. was compared to gene expression of the col-0 control set. Gene expression of the cax1-1 set exposed to magnesium sulfate treatment for 180 min. was compared to gene expression of the col-0 set exposed to magnesium sulfate treatment for 180 minutes.

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Gene expression profiling in soybean under aluminum stress: mechanisms of magnesium amelioration of aluminum toxicity

2010-10-04 | GSE18518 | GEO

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2014-05-21 | GSE44185 | GEO

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2014-05-21 | E-GEOD-44185 | biostudies-arrayexpress

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