Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome wide mapping of the effects of SMAD2/3 ligand treatment upon the distribution of senescence associated transcription factors

ABSTRACT: Analysis of SMAD2/3 and NFI binding in replicative senescent BJ fibroblasts upon treatment with SAMD2/3 regulating ligands.

ORGANISM(S): Homo sapiens

PROVIDER: GSE146569 | GEO | 2025/05/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Genome wide mapping of NFI and SMAD2/3 binding in senescence

Project description:ChIP-seq of NFI or SMAD2/3 was performed in young-quiescent or senescent BJ fibroblasts

2025-05-30 | GSE146564 | GEO

Genome wide mapping of open chromatin in senescence cells upon knockdown of senescence associated transcription factors

Project description:ATAC-seq was performed upon senescent BJ fibroblasts upon controls shRNA or knockdown of p65, SMAD2 or SMAD3, or NFI family members, in order to determine the role of each factor upon senescence associated enhancers.

2025-05-30 | GSE146572 | GEO

Genome wide expression analysis of senescent BJ fibroblasts in the presence or absence of various SMAD2/3 regulating molecules

Project description:BJ fibroblasts were grown to replicative senescence, and were then treated with control or SMAD2/3 regulating ligands. RNA was then harvested for RNA-seq.

2025-05-30 | GSE146580 | GEO

Genome wide mapping of JMJD6 binding in the context of experiments exploring the enhancer program of senescence

Project description:Analysis of JMJD6 binding relative to the epigenomic landscape of BJ fibroblasts from young to replicative senescent.

2025-05-30 | GSE146562 | GEO

Genome wide mapping of histone mark and transcription factor binding in the context of experiments exploring the enhancer program of senescence II

Project description:Analysis of histone and transcription factor epigenomic landscape of BJ fibroblasts from young to replicative senescent

2025-05-30 | GSE146571 | GEO

Genome wide mapping of histone mark and transcription factor binding in the context of experiments exploring the enhancer program of senescence I

Project description:Analysis of histone and transcription factor epigenomic landscape of BJ fibroblasts from young to replicative senescent

2025-05-30 | GSE146559 | GEO

Genome wide expression analysis of high passage growth arrested BJ fibroblasts maintained or withdrawn from rapamycin maintenance, in the presence or absence of various SMAD2/3 regulating molecules

Project description:BJ fibroblasts were grown in the presence of rapamycin until reaching growth arrest at high passages, at which point cells were maintained in or withdrawn from rapamycin, while also being treated with control or SMAD2/3 regulating ligands. RNA was then harvested for RNA-seq

2025-05-30 | GSE146579 | GEO

Genome wide mapping of NFI and SMAD2/3 binding in senescence

Project description:Genome wide mapping of NFI and SMAD2/3 binding in senescence

| PRJNA610870 | ENA

Regulation of Lipids is Central to Replicative Senescence

Project description:Cellular replicative senescence, a state of permanent cell-cycle arrest that occurs following an extended period of cell division in culture, has been linked to organismal aging, tissue repair and tumorigenesis. In this study, we comparatively investigated the global lipid profiles and mRNA content of proliferating and senescent-state BJ fibroblast cells. We found that both the expression levels of lipid-regulating genes, as well as the abundance of specific lipid families, are actively regulated. We further found that 19 polyunsaturated triacylglycerol species showed the most prominent changes during replicative senescence. We argue that diversion of polyunsaturated fatty acids to glycerolipid biosynthesis could be responsible for the accumulation of specific triacylglycerols. This, in turn, could be one of the cellular mechanisms to prevent lipotoxicity under increased oxidative stress conditions observed during replicative senescence. Collectively, our results place regulation of specific lipid species to a central role during replicative senescence.

2017-03-31 | GSE94280 | GEO

Identification of differentially expressed genes between senescence and senescence bypass cells

Project description:We applied RNA-seq analysis to control and senescent human primary BJ fibroblast cells (senescence induced by activation of the oncogenic RASG12V gene), as well as in BJ cells that fully or partially bypass oncogene-idnuced senescence (OIS) due to knock-down of either p53 or BRD7 or LncRNA-OIS1 (using 4 different shRNAs).

2018-01-29 | GSE106414 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data