Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE146667 | GEO | 2020/03/10

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events [Figure 8 mRNA data]

Project description:Analysis of rhythmonome gene expression in cardiac myocytes derived from human induced pluripotent stem cells Cardiac electrical activity is controlled by the carefully orchestrated activity of more than a dozen different ion conductances. Yet, there is considerable variability in cardiac ion channel expression levels both within and between subjects. In this study we tested the hypothesis that variations in ion channel expression between individuals are not random but rather there are modules of co-expressed genes and that these modules make electrical signaling in the heart more robust. Meta-analysis of 3653 public RNA-Seq datasets identified a strong correlation between expression of CACNA1C (L-type calcium current, ICaL) and KCNH2 (rapid delayed rectifier K+ current, IKr), which was verified in mRNA extracted from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM). In silico modeling, validated with functional measurements in hiPSC-CM, indicates that the co-expression of CACNA1C and KCNH2 limits the variability in action potential duration and reduces susceptibility to early afterdepolarizations, a surrogate marker for pro-arrhythmia.

2020-03-10 | GSE146665 | GEO

Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events [Figure 2 mRNA data]

2020-03-10 | GSE146664 | GEO

Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events

Project description:Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events

| PRJNA611588 | ENA

Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events [Figure 8 mRNA data]

Project description:Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events [Figure 8 mRNA data]

| PRJNA611595 | ENA

Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events [Figure 2 mRNA data]

Project description:Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events [Figure 2 mRNA data]

| PRJNA611596 | ENA

Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events.

Project description: Not available

| S-EPMC8785951 | biostudies-literature

Expression Profiling of Calcium Channels and Calcium-Activated Potassium Channels in Colorectal Cancer.

Project description: Not available

| S-EPMC6521016 | biostudies-literature

Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection.

Project description: Not available

| S-EPMC8368210 | biostudies-literature

Heteromeric KV2/KV8.2 Channels Mediate Delayed Rectifier Potassium Currents in Primate Photoreceptors.

Project description: Not available