Genomics

Dataset Information

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Genome-wide ETS-1 binding profile to chromatin in human CD4+ T lymphocytes [ChIP-seq]


ABSTRACT: In response to pathogenic threats, naïve T cells rapidly transition from a quiescent to activated state, yet the underlying mechanisms are incompletely understood. We investigated the dynamics of mRNA translation kinetics and protein turnover in human naïve and activated T cells. Our datasets uncovered that transcription factors maintaining T cell quiescence had constitutively high turnover, which facilitated their depletion upon activation. Our data elucidate new insights into how T cells maintain a prepared state to mount a rapid immune response.

ORGANISM(S): Homo sapiens

PROVIDER: GSE146787 | GEO | 2020/05/11

REPOSITORIES: GEO

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