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Influence of the early stress of maternal separation on the prefrontal cortex transcriptome

ABSTRACT: Exposure to early stress (ES) is known to enhance adult vulnerability for anxiety and depressive behaviors. The molecular and cellular pathways altered in response to ES that contribute to the establishment of a substrate for susceptibility to adult psychopathology are not well understood. Focusing on the prefrontal cortex (PFC), a brain region implicated in the modulation of emotional responses, we examined the consequences of the early stress experience of maternal separation (MS) on the adult PFC transcriptome. Microarray analysis identified alterations in genes associated with signal transduction, neuronal excitability, G-protein signaling and stress responses in the PFC of adult animals previously exposed to ES. Our results also indicated that the pattern of gene expression changes observed in ES animals contains a component in common with that induced by 5-HT2A/C receptor stimulation in control animals, suggesting enhanced 5-HT2A/C receptor-mediated signaling in ES animals. Further, our microarray results reveal that a history of ES alters the DOI-induced transcriptome in the PFC.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE14720 | GEO | 2010/08/20

SECONDARY ACCESSION(S): PRJNA112177

REPOSITORIES: GEO

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Influence of the early stress of maternal separation on the prefrontal cortex transcriptome

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