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Deciphering a distinct regulatory network of TEAD4, CDX2 and GATA3 in humans for trophoblast transition from embryonic stem cells

ABSTRACT: In this study, we perform multiple gain- and loss-of-function of TEAD4, CDX2 or GATA3 to study their roles in the trophoblast transition from BMP4-treated human embryonic stem cells (hESCs). Although hESCs with TEAD4 deletion maintain in pluripotency, their potential of trophoblast transition is attenuate. We then performed large-scale transcriptome analysis to explore more information.

ORGANISM(S): Homo sapiens

PROVIDER: GSE147224 | GEO | 2023/03/17

REPOSITORIES: GEO

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Gata3 acts alongside Cdx2 to promote trophoblast gene expression downstream of Tead4 during mouse development

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TEAD4

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