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RNAseq of rhabdomyosarcoma cells after treatment with SGI-110 and/or Dasatinib

ABSTRACT: Patients with metastatic or recurrent rhabdomyosarcoma, the most common childhood soft tissue sarcoma, continue to do poorly and new treatments are needed. In this study we evaluated a novel combination therapy using a dna methyltransferase inhibitor, SGI-110, and the SRC family kinase inhibitor, Dasatinib. To understand the transcriptional changes that occur after treatment with SGI-110 with and without Dasatinib we performed RNAseq on two human RMS cell lines (Rh30 and RD) after 5 days of drug treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE147240 | GEO | 2021/04/30

REPOSITORIES: GEO

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