Transcriptomics,Genomics

Dataset Information

34

Gene expression profiling in differential cognitive outcomes in aging: Dentate Gyrus


ABSTRACT: Functional alterations in medial temporal lobe structures, particularly the hippocampus, are central to age-related deficits in episodic memory. Research in aging laboratory animals has characterized physiological and cellular alterations in the hippocampus that occur in association with the presence and severity of such cognitive impairment. The current study compares alterations across hippocampal subregions by gene expression profiling in a rat model that closely mirrors individual differences in neurocognitive features of aging humans across a spectrum of outcomes, including both impaired memory and preserved function. Using mRNA profiling of the CA1, CA3 and dentate gyrus subregions, we have distinguished between gene groups and pathways related to chronological age and those specifically associated with impaired or preserved cognitive ability in aged rats. We confirmed earlier reported changes in gene groups related to inflammation and oxidative stress in multiple subregions and found these to be more associated with chronological age than cognitive function per se. The CA3 profile was best able to segregate aged impaired, aged unimpaired and young subject groups from each other. Characterization of gene changes that distinguished preserved from impaired function among the aged animals found altered expression of synaptic plasticity and neurodegenerative disease-related genes. Together these gene changes suggest recruitment of adaptive mechanisms that mediate synaptic plasticity to maintain function and structural integrity in aged unimpaired rats that does not occur in aged impaired animals. Overall design: RNA samples from DG region of the hippocampi of young animals, aged animals with unimpaired spatial learning, and aged animals with impaired spatial learning were compared to one another using Affymetrix GeneChip Rat Genome 230 2.0 arrays.

INSTRUMENT(S): [Rat230_2] Affymetrix Rat Genome 230 2.0 Array

SUBMITTER: Carlo Colantuoni  

PROVIDER: GSE14725 | GEO | 2009-11-01

SECONDARY ACCESSION(S): PRJNA114345

REPOSITORIES: GEO

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Publications

Prominent hippocampal CA3 gene expression profile in neurocognitive aging.

Haberman Rebecca P RP   Colantuoni Carlo C   Stocker Amy M AM   Schmidt Alexandra C AC   Pedersen Jan T JT   Gallagher Michela M  

Neurobiology of aging 20091113 9


Research in aging laboratory animals has characterized physiological and cellular alterations in medial temporal lobe structures, particularly the hippocampus, that are central to age-related memory deficits. The current study compares molecular alterations across hippocampal subregions in a rat model that closely mirrors individual differences in neurocognitive features of aging humans, including both impaired memory and preserved function. Using mRNA profiling of the CA1, CA3 and dentate gyrus  ...[more]

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