The role of TMEM43 in cardiac fibrosis and dysfunction

ABSTRACT: Deletion of Tmem43 encoding nuclear membrane protein TMEM43, specifically in mouse cardiac myocytes leads to cardiac fibrosis and dysfunction. Temporal RNA-seq identified early and late trascriptomic changes and implicates TGFb1 in the pathogenesis of ACM caused by Tmem43 haploinsufficiency.

ORGANISM(S): Mus musculus

PROVIDER: GSE147317 | GEO | 2021/02/26

REPOSITORIES: GEO