Human ESC-based modeling of H3.3G34R-mutant high grade glioma

ABSTRACT: H3.3G34R-mutant gliomas are lethal tumors of the cerebral hemispheres, with unknown mechanisms of topographic specificity and tumorigenicity. We developed a human embryonic stem cell (hESC)-based model of H3.3G34R-mutant glioma that recapitulates the anatomical and genetic characteristics of the patient tumors.

ORGANISM(S): Homo sapiens

PROVIDER: GSE147543 | GEO | 2021/02/25

REPOSITORIES: GEO