TbRAP1's dsDNA binding activity plays an important role in subtelomeric gene expression regulation

ABSTRACT: We examine the function of the TbRAP1 DB domain in gene expression regulation in Trypanosoma brucei that causes human African trypanosomiasis. TbRAP1 is required for normal VSG monoallelic expression, a key aspect of antigenic variation that is used by T. brucei to evade the host immune response.

ORGANISM(S): Trypanosoma brucei brucei

PROVIDER: GSE147734 | GEO | 2020/09/18

REPOSITORIES: GEO