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Loss of Musashi-1 inhibits breast cancer metastasis via regulation of Timp3/Mmp9

ABSTRACT: To investigate the molecular mechanism of Msi1 in breast cancer metastasis, we performed transcriptome profiling at 16 weeks of primary tumor samples between ctrl and Msi1 cko mice, We performed a pathway enrichment analysis of the transcriptome data, the enriched KEGG pathways are mostly related to cellular adhesion, such as Focal adhesion, cell adhesion molecular (CAM), ECM-receptor interaction and regulation of actin cytoskeleton, which are closely related to the formation of invadopodia.

ORGANISM(S): Mus musculus

PROVIDER: GSE148095 | GEO | 2021/06/22

REPOSITORIES: GEO

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