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Lasp1 gene deletion: Effect on gene expression in the gastric mucosa

ABSTRACT: Comparative analysis of gene expression in murine gastric fundic mucosa in wild-type and Lasp1-null littermates. The data provide a comprehensive overview of genes expressed in the mouse gastric mucosa and show that the expression of several known and unidentified genes is modified by disruption of the Lasp1 gene. Keywords: Genotypic comparison

ORGANISM(S): Mus musculus

PROVIDER: GSE14813 | GEO | 2009/02/13

SECONDARY ACCESSION(S): PRJNA112049

REPOSITORIES: GEO

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Lasp1 gene deletion: Effect on gene expression in the gastric mucosa

Project description:Comparative analysis of gene expression in murine gastric fundic mucosa in wild-type and Lasp1-null littermates. The data provide a comprehensive overview of genes expressed in the mouse gastric mucosa and show that the expression of several known and unidentified genes is modified by disruption of the Lasp1 gene. Keywords: Genotypic comparison Total mRNA isolated from fundic gastric mucosae of three-month old mice, C57Bl/6Ncr strain, was used for this comparison.

2010-06-23 | E-GEOD-14813 | biostudies-arrayexpress

CC10 gene deletion: Effect on gene expression in the sinonasal mucosa

2010-12-01 | GSE20969 | GEO

CC10 gene deletion: Effect on gene expression in the sinonasal mucosa

Project description:Comparative analysis of gene expression in murine sinonasal mucosa in wild-type and CC10-knockout littermates with allergic eosinophilic chronic rhinosinusitis. The data provide a comprehensive overview of genes expressed in the mouse sinonasal mucosa and show that the expression of several known and unidentified genes is modified by disruption of the CC10 gene. Total RNA isolated from sinonasal mucosae of 6- to 8-week-old mice, C57BL/6 strain, was used for this comparison. Three groups: wild-type control, wild-type with allergic eosinophilic chronic rhinosinusitis, and CC10-knockout with allergic eosinophilic chronic rhinosinusitis.

2010-12-01 | E-GEOD-20969 | biostudies-arrayexpress

Lasp1 gene disruption is linked to enhanced cell migration and tumor formation

Project description:Chronic loss of Lasp1 alters the expression of other genes associated with cell motility/attachment, and/or other cellular functions. Results provide new information showing that loss of Lasp1 leads to up- and down-regulation of genes involved in cell motility/attachment/growth. Keywords: Genotype comparison Total RNA isolated from Lasp1-/- MEFs compared to Lasp1+/+ MEFs.

2010-06-23 | E-GEOD-14800 | biostudies-arrayexpress

Transcription profiling of mouse fundic mucosa in the presence/absence of gastrin and in gastrin-CCK double knockout mice

Project description:Fundic mucosa gene expression in wildtype vs gastrin knockout, gastrin replaced gastrin KO and gastrin-CCK double knockout mice; Fundic mucosal scraping RNA were isolated from WT, Gastrin Knockout, Gastrin replaced KO and Gastrin-CCK double knockout mice. Targets from three biological replicates of each were generated and the expression profiles were determined using Affymetrix murine 430A arrays. Comparisons between the sample groups allow the identification of genes with gastrin responsiveness and Gastrin-CCK double effect . Experiment Overall Design: 3 WT, 3 Gastrin KO, 3 Gastrin replaced KO and 3 Gastrin-CCK double Knockout fundic RNA replicates were analyzed

2008-06-13 | E-GEOD-4810 | biostudies-arrayexpress

gastric mucosa

Project description:gastric mucosa Raw sequence reads

| PRJNA508819 | ENA

Fundic mucosa gene expression in the presence/absence of gastrin and in gastrin-CCK double knockout mice.

Project description:Fundic mucosa gene expression in wildtype vs gastrin knockout, gastrin replaced gastrin KO and gastrin-CCK double knockout mice Fundic mucosal scraping RNA were isolated from WT, Gastrin Knockout, Gastrin replaced KO and Gastrin-CCK double knockout mice. Targets from three biological replicates of each were generated and the expression profiles were determined using Affymetrix murine 430A arrays. Comparisons between the sample groups allow the identification of genes with gastrin responsiveness and Gastrin-CCK double effect . Keywords: repeat

2007-05-03 | GSE4810 | GEO

Lasp1 gene disruption is linked to enhanced cell migration and tumor formation

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Regulation of matrix metalloproteinases (MMPs) expression and secretion by LIM and SH3 protein (LASP1)

Project description:The process of tumor invasion requires degradation of extracellular matrix by proteolytic enzymes. Cancer cells form protrusive invadopodia, which produce and release matrix metalloproteinases (MMPs) to degrade the basement membrane and thereby allowing metastasis. We investigated the effect of LASP1, a newly identified protein in invadopodia, on expression, secretion and activation of MMPs in invasive breast tumor cells. By analyzing and verifying microarray data sets and performing reporter assays, we demonstrate that LASP1 positively modulates the expression of c-Fos and AP-1 activity, and thereby up-regulates expression of MMP1, -3 and -9 in breast cancer cells. Furthermore, zymography assays and Western blot analysis revealed cytosolic LASP1 promotion of MMP vesicle secretion into the extracellular matrix, thus altering the microenvironment during cancer progression. The newly identified role of LASP1 in regulating matrix degradation by affecting MMP transcription and secretion elucidated the migratory potential observed in studies that investigated the upregulation of LASP1 in aggressive cancers.

2017-02-03 | GSE77584 | GEO

Gene expression by LASP1 knocked down in PC3 cells

Project description:The aim of this research was to confirm the regulatory effect of LASP1 on gene expression in the development of prostate cancer.

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