Transcriptomics

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Downregulation of anti-inflammatory A20 promotes immune escape of lung adenocarcinomas


ABSTRACT: We found that the potent anti-inflammatory enzyme A20 is a potent tumor suppressor and hence often downregulated in human and mouse lung adenocarcinoma. Comparison of gene expression profiles of A20 expressing versus A20 deficient lung tumor tissue samples revealed that loss of A20 enhanced the cellular response to interferons. This hypersensitivity to interferons was responsible to drive immune evasion of A20 deficient lung adenocarcinomas. ,

ORGANISM(S): Mus musculus

PROVIDER: GSE148194 | GEO | 2021/04/01

REPOSITORIES: GEO

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