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Resident macrophages promote homeostasis of hyaluronan-associated extracellular matrix in the mammary gland stroma

ABSTRACT: Tissue resident macrophages in the mammary gland are found in close association with epithelial structures and within the adipose stroma, and are important for mammary gland development and tissue homeostasis. While epithelial-associated macrophages have been linked to ductal development, the contributions of stromal macrophages to mammary gland homeostasis remain unknown. Using transcriptional profiling, we identify a distinct resident stromal macrophage subpopulation that is characterized by expression of Lyve-1, a receptor for the extracellular matrix component hyaluronan. This subpopulation is enriched in genes associated with extracellular matrix remodeling and is found to be specifically associated with hyaluronan-rich regions within the mammary stroma. Furthermore, macrophage depletion leads to increased accumulation of hyaluronan-associated extracellular matrix in the mammary stroma. These results demonstrate the presence of a distinct subpopulation of macrophages and provide insights into the functional contributions of these macrophages to stromal homeostasis in the mammary gland.

ORGANISM(S): Mus musculus

PROVIDER: GSE148207 | GEO | 2020/05/31

REPOSITORIES: GEO

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Resident macrophages promote homeostasis of hyaluronan-associated extracellular matrix in the mammary gland stroma

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