Mechanism of translation inhibition by type II GNAT toxins: AtaT, TacT, and ItaT

ABSTRACT: Type II toxin-antitoxin (TA) systems are two-gene modules widely distributed among prokaryotes. GNAT toxins associated with the DUF1778 antitoxins represent a large family of type II TAs. GNAT toxins inhibit cell growth by disrupting translation via acetylation of aminoacyl-tRNAs. Using ribosome profiling, we investigated the in vivo substrate specificity of three GNAT toxins: AtaT2, TacT3, and ItaT.

ORGANISM(S): Escherichia coli str. K-12 substr. MG1655

PROVIDER: GSE148424 | GEO | 2020/06/17

REPOSITORIES: GEO