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Transcriptomic Analysis of the Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds [RNA-Seq]

ABSTRACT: A global profiling of changes in the gene signature of DCIS regulated by vitamin D compounds was examined in MCF10DCIS mammospheres.

ORGANISM(S): Homo sapiens

PROVIDER: GSE148546 | GEO | 2020/06/09

REPOSITORIES: GEO

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Transcriptomic Analysis of the Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds [Bisulfite-seq]

Project description:A global profiling of changes in the gene signature of DCIS regulated by vitamin D compounds was examined in MCF10DCIS mammospheres.

2020-06-09 | GSE148547 | GEO

Myoepithelial cell perturbations in BRCA mutation carriers and in DCIS (ductal carcinoma in situ)

Project description:We describe the gene expression profiles and enhancer landscape of normal myoepithelial cells and perturbations of these in BRCA1 and BRCA2 mutation carriers and in DCIS. We identified a myoepithelial transcription regulatory network orchestrated by p63 and TCF7 and defined the genomic targets of these transcription factors by ChIP-seq. While the majority of myoepithelial cells co-express p63 and TCF7 in normal breast of healthy women, the frequency of these cells is significantly lower in BRCA1 mutation carriers and in DCIS. Downregulation of p63 in MCF10DCIS cells leads to loss of myoepithelial cells and invasive tumors, whereas overexpression of TCF7 enhances tumor growth. Our findings suggest that loss of normal myoepithelial cell function facilitates in situ to invasive carcinoma transition and it may also enhance tumor initiation in BRCA mutation carriers.

2021-04-27 | GSE113795 | GEO

Myoepithelial cell perturbations in BRCA mutation carriers and in DCIS (ductal carcinoma in situ)

2019-08-20 | GSE113909 | GEO

Transcriptomic Analysis of the Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds

Project description:Transcriptomic Analysis of the Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds

| PRJNA625007 | ENA

Transcriptomic Analysis of the Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds [RNA-Seq]

Project description:Transcriptomic Analysis of the Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds [RNA-Seq]

| PRJNA624999 | ENA

Transcriptomic Analysis of the Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds [Bisulfite-seq]

Project description:Transcriptomic Analysis of the Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds [Bisulfite-seq]

| PRJNA625010 | ENA

Progression of ductal carcinoma in situ to invasive breast cancer

Project description:Ductal carcinoma in situ (DCIS) is a precursor lesion that can give rise to invasive breast cancer (IBC). It has been proposed that both the nature of the lesion and the tumor microenvironment play key roles in progression to IBC. Here, laser capture microdissected tissue samples from epithelium and stroma in normal breast, pure DCIS, and pure IBC were employed to define key gene expression profiles associated with disease progression. Tumor and matching stroma were profiled for 9 DCIS patients, 10 IBC patients, and 3 normal breast. Differential gene expression was evaluated for paired normal stroma versus normal epitelium samples, paired DCIS stroma versus DCIS epitelium samples, paired IBC stroma versus IBC epitelium, IBC stroma versus DCIS stroma, and IBC epithelium versus DCIS epithelium.

2012-03-31 | E-GEOD-33692 | biostudies-arrayexpress

Transcriptomic Analysis of the Regulation of Cancer Stemness in Breast Ductal Carcinoma In Situ by Vitamin D Compounds

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-06-09 | GSE148548 | GEO

Analysis of the Transcriptome: Regulation of Cancer Stemness in Breast Ductal Carcinoma <i>In Situ</i> by Vitamin D Compounds.

Project description: Not available

| S-EPMC7415686 | biostudies-literature

Array-based genome-wide transcriptome analysis of Ductal carcinoma in situ (DCIS)

Project description:Ductal carcinoma in situ (DCIS) is the presence of abnormal cells inside a milk duct in the breast. DCIS is considered the earliest form of breast cancer. DCIS is noninvasive, meaning that it does not spread out of the milk duct and has a low risk of becoming invasive.

2021-06-14 | GSE169393 | GEO

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