CD5 levels define functionally heterogeneous populations of naïve human CD4+ T cells

ABSTRACT: Studies from mouse models show that differences in self-reactivity, as read-out by CD5 levels, identifies naïve T cell subsets with distinct functional properties during an immune response. Whether CD5 levels can also be used to parse functional biases in naive human CD4+ T cells is incompletely understood. Our study establishes CD5 as a reliable marker of T cell self-reactivity and functional heterogeneity in human CD4+ T cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE148662 | GEO | 2020/04/15

REPOSITORIES: GEO