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The transcription factor CLAMP is required for embryonic and post-embryonic neurogenesis in Drosophila melanogaster.

ABSTRACT: Abstract: During brain development, neural stem cells undergo multiple rounds of division before they give rise to mature brain cells. This process is characterized by elaborate waves of genomic, molecular and cellular transformations, orchestrated by transcription factors (TF) along spatiotemporal axes. We show that the TF Chromatin-linked adaptor for MSL proteins (CLAMP) is required both for embryonic and post-embryonic neurogenesis. Clamp deletion, causes impaired chromosomal separation/asymmetric cell division and promotes precocious neurogenesis at the expense of glial cell formation resulting in severely impaired optic lobe development. mRNA-sequencing of clamp mutant embryos and larvae revealed downregulation in pathways controlling stemness, proliferation, and glial development while stem cell-niche survival pathways are mobilized causing accumulation of brain lipid droplets. Collectively, our results suggest CLAMP promotes neuronal and glial cell generation and modulates neuroblast proliferation via cell-intrinsic and niche-dependent mechanisms from the embryonic through the larval stages.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE148704 | GEO | 2026/08/19

REPOSITORIES: GEO

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The transcription factor CLAMP is required for embryonic and post-embryonic neurogenesis in Drosophila melanogaster.

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