Effects of folic acid withdrawal on transcriptomic profiles in murine triple-negative breast cancer cell lines

ABSTRACT: We have previously shown that withdrawal of folic acid led to metabolic reprogramming and a less aggressive phenotype in a cell model of triple-negative breast cancer (TNBC). Herein, we evaluate the effects of folic acid withdrawal on transcriptomic profiles in these cells. Murine cell lines were originally derived from a pool of spontaneous mammary tumors grown in MMTV-Wnt1 transgenic mice. Based on their differential molecular characteristics and metastatic potential, these cell lines were previously characterized as non-metastatic epithelial (E-Wnt), non-metastatic mesenchymal (M-Wnt) and metastatic mesenchymal (metM-Wntliver) cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE148738 | GEO | 2020/04/16

REPOSITORIES: GEO