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In-situ cell-type specific chromatin topologies in the brain revealed by genome architecture mapping

ABSTRACT: We report the application of genome architecture mapping in specific cell types in mouse brain. We generated cell-type specific chromatin contact maps in mouse dopaminergic neurons from the midbrain ventral tegmental area (VTA DN), pyramidal glutamatergic neurons from the cornus ammonis 1 region of the hippocampus (CA1 PGN), and non-neuronal post-mitotic oligodendrocytes from the somatosensory cortex (SSC_Olig). We explored cell-type specific chromatin topologies genome-wide at multiple genomic scales. Our data demonstrates that chromatin organization is cell type specific and reflects cell specialization at all genomic scales.

ORGANISM(S): Mus musculus

PROVIDER: GSE148792 | GEO | 2021/08/27

REPOSITORIES: GEO

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