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Adaptable durable human endothelial cells for organogenesis and tumorigenesis

ABSTRACT: ETV2 resets endothelial cells' fate, confering them with vascular mallebility, which results in long-term stable vessel formation (R-VEC). R-VECs adapt to normal colon organoids and maladapt to colorectal cancer organoids

ORGANISM(S): Homo sapiens

PROVIDER: GSE148996 | GEO | 2020/05/21

REPOSITORIES: GEO

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Adaptable durable human endothelial cells for organogenesis and tumorigenesis

Project description:ETV2 resets endothelial cells' fate, confering them with vascular mallebility, which results in long-term stable vessel formation.

2020-03-31 | GSE147746 | GEO

Adaptable durable human endothelial cells for organogenesis and tumorigenesis

Project description:ETV2 resets endothelial cells' fate, confering them with vascular mallebility, which results in long-term stable vessel formation.

2020-05-01 | GSE131039 | GEO

Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.

Project description: Not available

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Efficient direct reprogramming of c-Kit− mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression

Project description:ETS transcription factors ETV2, FLI1 and ERG1 specify pluripotent stem cells into endothelial cells (PSC-ECs). However, these PSC-ECs are unstable and often drift towards non-vascular cell fates. We show that human mid-gestation c-Kit- lineage-committed amniotic cells (ACs) can be reprogrammed into induced vascular endothelial cells (rAC-VECs). Transient ETV2 expression in ACs generated immature iVECs, while co-expression with FLI1/ERG1 endowed rAC-VECs with a vascular repertoire and morphology matching mature ECs. Brief TGFb-inhibition functionalizes VEGFR2 signaling, augmenting specification of ACs into rAC-VECs. Genome-wide transcriptional analyses showed that rAC-VECs are similar to adult ECs in which vascular-specific genes are expressed and non-vascular genes are silenced. Functionally, rAC-VECs form stable vasculature in Matrigel plugs and regenerating livers. Thus, short-term ETV2 expression and TGFb-inhibition along with constitutive ERG1/FLI1 co-expression reprogram mature ACs into generic rAC-VECs with clinical-scale expansion potential. Public banking of HLA-typed rAC-VECs would establish a vascular inventory for treatment of genetically diverse disorders. Transcriptome sequencing of clonal and non-clonal rAC-VECs, HUVECs, LSECs, CD34+/Lin-, BMS

2012-10-30 | E-GEOD-40291 | biostudies-arrayexpress

Adaptable durable human endothelial cells for organogenesis and tumorigenesis

Project description:Adaptable durable human endothelial cells for organogenesis and tumorigenesis

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Adaptable durable human endothelial cells for organogenesis and tumorigenesis

Project description:Adaptable durable human endothelial cells for organogenesis and tumorigenesis

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Adaptable durable human endothelial cells for organogenesis and tumorigenesis

Project description:Adaptable durable human endothelial cells for organogenesis and tumorigenesis

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Single-cell transcriptome Atlas reveals embryonic endothelial heterogeneity

Project description:Mature endothelial cells (ECs) are heterogeneous, with subtypes defined by tissue origin and by position within the vascular bed. Here, we performed scRNA-seq with mouse embryonic ECs and identified 19 subclusters, including Etv2+Bnip3+ early EC progenitors. Most of these subtypes were grouped by their vascular-bed types, while ECs from brain, heart and liver were grouped by their tissue origins. Compared to arterial ECs (aECs), embryonic venous (vECs) and capillary ECs (cECs) shared less markers with their adult counterparts. cECs showed some venous characteristics. One cEC cluster with both venous and capillary features served as a branch point for aEC and vEC lineages. aECs and vECs showed distinct transcriptional regulatory networks.

2024-01-25 | GSE216970 | GEO

Efficient direct reprogramming of c-Kit− mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression

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Effects of differences in donors and passage numbers of endothelial progenitor cell (EPC)-derived vascular endothelial cells (VECs) on the phenotype determination of VECs (type-I versus type-II).

Project description:EPC-derived VECs (EPCdECs) are categorized into two group according to their effects on the proliferation of vascular smooth muscle cells: type-I pro-proliferative VECs and type-II anti-proliferative VECs. Type-II EPCdECs were converted to type-I VECs by repetitive subcultures. Not only subculture-dependent cellular stresses but also donor differences greatly affect the phenotype determination of VECs. By comparing the gene expression profiles of type-II EPCdEC of the first donor (EPC1dEC) at early passage and those of type-II EPC1dEC at late passage and EPCdEC of the second donor at early passage, characteristic gene expression patterns that discriminate Type-I and type-II EPCdECs will be comprehended. Totally three samples of type-I EPC-derived VECs (EPC1dEC[P12], EPC2dEC[P7]) and type-II EPC-derived VEC (EPC1dEC[P7]) were subjected to the analyses.

2014-09-30 | E-GEOD-61000 | biostudies-arrayexpress

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