Transcriptomics,Genomics

Dataset Information

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Next generation sequencing quantitatively analyzes transcriptomes of primary CLL cells tranfected with non-specific control (NSC) or ZAP-70 siRNA (-anti-IgM dataset)


ABSTRACT: RNA seq profiles of primary CLL cells transfected with non-specific control (NSC) or ZAP-70 siRNA ± anti-IgM. This submission is -anti-IgM. Overall design: mRNA profiles of primary CLL cells tranfected with non-specific control (NSC) or ZAP-70 siRNA (± anti-IgM) were generated by deep sequencing, in two patients, each in triplicate.

INSTRUMENT(S): Illumina HiSeq 4000 (Homo sapiens)

ORGANISM(S): Homo Sapiens

SUBMITTER: Irina Mohorianu  

PROVIDER: GSE149020 | GEO | 2022-04-19

REPOSITORIES: GEO

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Publications


The expression of ZAP-70 in a subset of chronic lymphocytic leukemia (CLL) patients strongly correlates with a more aggressive clinical course, although the exact underlying mechanisms remain elusive. The ability of ZAP-70 to enhance B-cell receptor (BCR) signaling, independently of its kinase function, is considered to contribute. We used RNA-sequencing and proteomic analyses of primary cells differing only in their expression of ZAP-70 to further define how ZAP-70 increases the aggressiveness  ...[more]

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