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Pharmacologic inhibition of EphB3 receptor kinase ameliorates EAE

ABSTRACT: To evaluate the potential of EphB3 as a therapeutic target during CNS inflammation, we induced EAE in B6 WT mice and starting at the peak of the disease we initiated treatment with A38 administered. A38 administration ameliorated EAE, and the transcriptional analysis of the astrocytes and microglia revealed the decreased expression of genes associated to inflammation and neurodegeneration.

ORGANISM(S): Mus musculus

PROVIDER: GSE149135 | GEO | 2022/02/25

REPOSITORIES: GEO

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Pharmacologic or genetic inhibition of EphB3 receptor kinase impacts CNS pathology during progressive EAE

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Exon Expression Changes in the Spinal Cords of Lewis Rats with Myelin Basic Protein-Induced Experimental Autoimmune Encephalomyelitis (EAE)

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