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Neurog3 gene dosage effect on the differentiaiton of intestinal enteroendocrine progenitors

ABSTRACT: Analysis of FACS-sorted intestinal Neurog3+/+ and Neurog3+/- cells from Neurog3 fluorencent reporter mice carrying two-(+/+) or one- (+/-) Neurog3 alleles. In the intestine, Neurog3 is an enteroendocrine (EE) lineage determinating transcription factor that transiently expressed in early EEC progenitors. By comparison the molecular profiles of Neurog3+/+ and Neurog3+/- cells, we hypothesized that Neurog3 gene dosage regulates the allocation of EE progenitor fates towards EEC vs. goblet cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE149203 | GEO | 2020/08/13

REPOSITORIES: GEO

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