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Characterisation of gene expression changes in T cells from patients presenting with AML compared with healthy T cells

ABSTRACT: Work previously published by our group has demonstrated that T cells from patients with chronic lymphocytic leukaemia (CLL) show differentially regulated genes compared with healthy T cells. This study was initiated to examine if these gene expression changes were unique to CLL T cells or common to an alternative leukaemia, acute myeloid leukaemia (AML). Keywords: Comparison of immune cells in health and disease

ORGANISM(S): Homo sapiens

PROVIDER: GSE14924 | GEO | 2009/05/20

SECONDARY ACCESSION(S): PRJNA111913

REPOSITORIES: GEO

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Transcription profiling of human T cells from patients presenting with AML compared with healthy T cells

Project description:Work previously published by our group has demonstrated that T cells from patients with chronic lymphocytic leukaemia (CLL) show differentially regulated genes compared with healthy T cells. This study was initiated to examine if these gene expression changes were unique to CLL T cells or common to an alternative leukaemia, acute myeloid leukaemia (AML). Experiment Overall Design: The study was composed of four groups of samples: AML CD4 (n=10), AML CD8 (n=10), Healthy CD4 (n=10), Healthy CD8 (n=11). AML samples were chosen to represent the range of FAB types, prognostic groups and patient outcomes. Healthy T cells were obtained from volunteers. The purity of isolated T cell fractions was greater than 70% in all cases.

2009-06-01 | E-GEOD-14924 | biostudies-arrayexpress

miRNAseq CLL38

Project description:miRNAseq of chronic lymphocytic leukaemia (CLL) subsets comprising of Unmutated CLL and Mutated CLL. Mutated CLL cases were further subdivided based on B cell receptor signalling capacity.

2023-05-11 | E-MTAB-12017 | biostudies-arrayexpress

RNA sequencing of thirty-eight basal tumour samples from CLL patients

Project description:RNAseq of chronic lymphocytic leukaemia (CLL) subsets comprising of Unmutated CLL and Mutated CLL. Mutated CLL cases were further subdivided based on B cell receptor signalling capacity.

2023-05-11 | E-MTAB-12023 | biostudies-arrayexpress

DNA methylation arrays of thirty-eight basal tumour samples from CLL patients

Project description:DNA methylation arrays of chronic lymphocytic leukaemia (CLL) subsets comprising of Unmutated CLL and Mutated CLL. Mutated CLL cases were further subdivided based on B cell receptor signalling capacity.

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Differential transcription in cell sorted paired TLR9hi and TLR9lo CLL samples

Project description:This study set out to establish whether sub-populations of chronic lymphocytic leukaemia (CLL) cells, with different expression of cell surface TLR9 expression, have altered gene transcription signatiures.

2022-01-01 | GSE147561 | GEO

Human Chronic Lymphocytic Leukaemia cells: Untreated vs mithramycin-treated

Project description:Transcriptional profiling of primary human malignant B cells from patients with chronic lymphocytic leukaemia (CLL), comparing untreated CLL cells with CLL cells that have been treated 24h with 200nM mithramycin. Mithramycin intercalates into GC-rich regions of DNA to inhibit binding of the transcription factor SP1. The goal of this experiment is to gain understanding of the genes regulated by SP1 in primary CLL cells.

2022-12-14 | GSE210348 | GEO

RNAseq of Chronic Lymphocytic Leukaemia with and without anti-IgM treatment at 6 hrs and 24 hrs post-stimulation

Project description:Series of Chronic Lymphocytic Leukaemia (mix of U-CLL and M-CLL) with and without anti-IgM stimulation of the B cell receptor. RNA acquired at 6hrs and 24hrs post stimulation.

2022-02-21 | E-MTAB-11195 | biostudies-arrayexpress

Assessment of the role of the BCRs in transgenic models of chronic lymphocytic leukemia

Project description:we evaluated the capacity of different types of antigen/BCR interactions to induce leukemia in a transgenic mouse model of CLL Key words; B-cell antigen receptor (BCR), chronic lymphocytic leukaemia (CLL), T-cell leukemia (TCL)

2014-12-31 | GSE55240 | GEO

The inhibitory receptor Siglec-G controls the severity of chronic lymphocytic leukemia

Project description:Chronic Lymphocytic Leukaemia (CLL) is the most common leukemia in adults in the Western world. B cell receptor (BCR) signalling is known to be crucial for the pathogenesis and maintenance of CLL cells develop from mature CD5+ B cells. BCR signalling is regulated by the inhibitory co-receptor Siglec-G and Siglec-G-deficient mice have an enlarged CD5+ B1a cell population. Here, we determine how Siglec-G expression influences the severity of CLL.

2023-05-03 | GSE227678 | GEO

Nanda2013 - B cell chronic lymphocytic leukemia A model with immune response

Project description:B cell chronic lymphocytic leukemia - A model with immune response Seema Nanda 1, , Lisette dePillis 2, and Ami Radunskaya 3, 1. Tata Institute of Fundamental Research, Centre for Applicable Mathematics, Bangalore 560065, India 2. Department of Mathematics, Harvey Mudd College, Claremont, CA 91711 3. Department of Mathematics, Pomona College, Claremont, CA, 91711, United States Abstract B cell chronic lymphocytic leukemia (B-CLL) is known to have substantial clinical heterogeneity. There is no cure, but treatments allow for disease management. However, the wide range of clinical courses experienced by B-CLL patients makes prognosis and hence treatment a significant challenge. In an attempt to study disease progression across different patients via a unified yet flexible approach, we present a mathematical model of B-CLL with immune response, that can capture both rapid and slow disease progression. This model includes four different cell populations in the peripheral blood of humans: B-CLL cells, NK cells, cytotoxic T cells and helper T cells. We analyze existing data in the medical literature, determine ranges of values for parameters of the model, and compare our model outcomes to clinical patient data. The goal of this work is to provide a tool that may shed light on factors affecting the course of disease progression in patients. This modeling tool can serve as a foundation upon which future treatments can be based. Keywords: NK cell, chronic lymphocytic leukemia, mathematical model, T cell., B-CLL.

2020-01-09 | MODEL2001090002 | BioModels

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