RNA-seq analysis of helios deficient hematopoietic stem and progenitor cells.

ABSTRACT: Here we addressed the mRNA transcriptome of Long-Term Hematopoietic Stem Cells (LT-HSC) and Multipotent Progenitor (MPP) -3 and -4 purified from WT and Helios KO mice. By analyzing the differentially expressed genes among WT and KO condition we found that Helios deletion affects transcription mostly in the LT-HSC compartment and favor a megakaryocyte mRNA lineage priming at the expense of the lymphoid one.

ORGANISM(S): Mus musculus

PROVIDER: GSE149244 | GEO | 2021/08/13

REPOSITORIES: GEO